He was born September 26, 1813, in
Belleville, New Jersey where he grew up and received his education. In 1834, he moved to
New York City and started work in a drugstore, before using his learned trade to open his own drugstore in Houston in 1839. He partnered with George W. Kimball and expanded the business, making their first shipment of cotton to Boston in 1841. He married Kimball's sister Jeannette Ingals Kimball the same year. They had four children. Kimball drowned off the Florida coast while escorting a cotton shipment and investment funds to New York in 1842, leading Ennis into his involvement with the railroad as a better transport option that needed investment. Ennis started and was on the board of directors the
Houston and Texas Central Railway in 1853 along with
William R. Baker,
Paul Bremond,
Thomas William House,
William J. Hutchins and
William Marsh Rice. As mayor he supervised the
Houston Tap Railroad completion which was sold in 1858 and became the
Houston Tap and Brazoria Railway. He also promoted construction of the
Houston Ship Channel. ==Mayor of Houston==