The route that would become University Parkway was originally a rural road from US 301 east. At the time, US 301 turned west at University Parkway and continued north to Bradenton along present-day 15th Street (301 Boulevard). US 301 north of University Parkway would not be moved to its current alignment until 1985. University Parkway was extended east to connect with I-75 by the time the freeway opened through the area in 1981. It was designated as SR 610. University Parkway was heavily expanded in the early 1990s. At this time, it was widened to a multi-lane divided road from US 301 to I-75. The widening was jointly funded by both Sarasota and Manatee counties. Around the same time, University Parkway was extended west as a four-lane road from US 301 southwest to Desoto Road (
CR 778). Desoto Road from there west to US 41 was also widened to four lanes, which then became part of University Parkway linking it to US 41 and
Sarasota–Bradenton International Airport. The road between US 301 and Desoto Road was built on the route of a former railroad spur that once linked the two railroad lines in the area (part of the spur is still in place near US 301). University Parkway was also extended west from I-75 to provide access to the newly-developed
Lakewood Ranch by the time the first phase of that community was complete in 1995. In 2017, University Parkway's interchange with I-75 was converted to a
diverging diamond interchange. It was the first diverging diamond interchange in the state of
Florida and it is one of the largest diverging diamond interchanges in the country. ==Major intersections==