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COUP-TFI

COUP-TF1 also known as NR2F1 is a protein that in humans is encoded by the NR2F1 gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. == Interactions ==
Interactions
COUP-TFI has been shown to interact with: • BCL11A, • BCL11B, and • ESR1. ==Clinical==
Clinical
Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome. == References ==
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