Deracoxib

Deracoxib is used in dogs for the control of pain and inflammation associated with osteoarthritis and for the prevention of pain following orthopedic surgery or dental procedures. In cats, the use of deracoxib is not recommended. == Contraindications ==

Deracoxib is contraindicated for treatment of dogs with hypersensitivity to deracoxib or other NSAIDs, and dogs with gastro-intestinal ulcers, renal disease, hepatic disorders, hypoproteinemia, dehydration, or cardiac disease. Dogs with renal disease may need dose adjustment (if the benefits of the medication outweigh the risks), while those on concurrent diuretic therapy are at increased risk for NSAID toxicity and should not be given this medication. The concurrent use of deracoxib with steroids or other NSAIDs should be avoided. The safety of deracoxib has not been established in pregnant or nursing dogs or in dogs younger than 4 months of age. == Adverse effects ==

The most common adverse effects of treatment with deracoxib are vomiting, anorexia, lethargy and depression. Serious adverse effects, including ulcers which perforate the gastrointestinal tract, have occurred in dogs administered higher than recommended doses of deracoxib, or dogs administered deracoxib at the same time as (or soon after) other NSAIDs or corticosteroid medications. Documented adverse side effects include serious and sometimes fatal organ system damage or failure. Deracoxib can cause increased blood urea nitrogen (BUN) in a dose-dependent manner. Other side effects include increase in drinking or urination, jaundice, bloody or black stools, pale gums, hot spots, increased respiration (fast or heavy breathing), incoordination, and behavior changes. ==Pharmacology==

Deracoxib is a coxib class nonsteroidal anti-inflammatory drug (NSAID). At the doses used to treat dogs, deracoxib causes greater inhibition of than of , ==Society and culture==

In the U.S., deracoxib was first approved for use in dogs in 2002, under the trade name Deramaxx chewable tablets, sold by Novartis Animal Health. == References ==