The protein encoded by this gene is normally found in the membrane of the
endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved, and the released
cytoplasmic
transcription factor domain
translocates to the
nucleus. There it activates the
transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]. == Implications in Disease ==