•
Lennie James as Glen Boyle, Trauma Consultant and Team Leader •
Catherine Walker as Fiona Lomas, Vascular Surgical Registrar and Trauma Fellow •
Kimberley Nixon as Dr. Angharad ('Harry') Bennett-Edwards, Senior House Officer •
Neve McIntosh as Nicola Hicklin, Consultant Nurse, Acting Clinical Lead and Deputy Clinical Lead •
John MacMillan as Justin Costello, Staff Nurse •
Danny Kirrane as Billy Finlay, Operating Department Practitioner •
Prasanna Puwanarajah as Ramakrishna Chandramohan, Anaesthetics Registrar •
Peter Sullivan as Clive Archerfield, Clinical Lead Consultant and Major Incident Officer •
Mali Harries as Nerys Merrick, Ward Sister •
Paul Bazely as Giles Dhillon, Trauma Manager •
Emma Fryer as Rebecca Osgood, Orthopaedic Registrar • Juliet Oldfield as Shelley Imms,
Radiographer • Jack Fortune as Robert Street, Consultant General Surgeon •
Claire Skinner as Lorraine Rappaport, Consultant Trauma Surgeon, Consultant Vascular Surgeon and Trauma Team Leader • Orion Lee as Brian Zhao,
CT Radiographer
Guest cast • Maya Barcot as Tessa Yarwood (4 episodes) • Daphne Cheung as Debbie Wong (4 episodes) • Anna Koval as Ania Dubczek (4 episodes) • Kirsten Foster as Dalisay Guinto (3 episodes) • Garry Marriott as Lloyd Watson, Paramedic (2 episodes) •
Elliot Cowan as Tom Farrow, O/G Consultant (2 episodes) • Tim Faraday as Bob Webster (6 episodes) ==Episodes==