Cryptothecia demethylconfluentica is a corticolous (bark-dwelling) lichen in the family Arthoniaceae. It is a small crustose lichen that forms pale ochre-coloured crusts on tree bark in primary rainforest in northeastern Brazil. The species is distinguished by its powdery reproductive granules scattered across the thallus surface and by the presence of two specific chemical compounds in its tissues that are used to identify it. It was formally described in 2022 from material collected in Parque Nacional Serra de Itabaiana in Sergipe State and remains known only from this locality.