Cyclohexylamine

Cyclohexylamine is produced by two routes, the main one being the complete hydrogenation of aniline using some cobalt- or nickel-based catalysts: : It is also prepared by alkylation of ammonia using cyclohexanol. ==Applications==

Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide-based reagents used as accelerators for vulcanization. The amine itself is an effective corrosion inhibitor. It has been used as a flushing aid in the printing ink industry. Drugs List It is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators). Most of the drugs in the following list fall into the arena of sulfonamide hypoglycemics though: • Acetohexamide • Amesergide • Bromhexine • Brovanexine • CGP-11112 (not actually made from CyNH2 but CyN containing). • Cilostazol • Clorexolone • Cyclamate • Enpromate • Esaprazole • Glibenclamide • Glicaramide • Gliquidone • Glipizide • Glisindamide • Glisolamide • Glycyclamide Patent (beispiel 5): • Glyhexamide • Hexazinone • Hexylcaine • Hydroxyhexamide • Lomustine • Metahexamide • Timegadine • Thiohexamide • U-37883A HCl: [57568-80-6] Hair Growth Inhibition: Pharmacol: ==Toxicity==

Cyclohexylamine has a low acute toxicity with LD50 (rat; p.o.) = 0.71 ml/kg Like other amines, it is corrosive. Cyclohexylamine is listed as an extremely hazardous substance as defined by Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act. The National Institute for Occupational Safety and Health has suggested workers not be exposed to a recommended exposure limit of over 10 ppm (40 mg/m3) over an eight-hour workshift. ==References==