Cyclopsettidae is a family of flatfish primarily native to the coastlines of the Americas, with a few species found off the western coast of Africa. Members of this family were previously placed in Paralichthyidae until a 2019 study, which found this placement to be paraphyletic, and described a new family for them. The closest relatives of the Cyclopsettidae are thought to be the Bothidae, based on both genetic and morphological data.