A group of college kids – Allison, Chad, Chloe, Chuck, Jason, Naomi, Todd, Mitch, and Mike – go on a camping trip in
West Virginia. While at a gas station, they encounter Tucker and Dale, two well-meaning
hillbillies who recently bought an abandoned lakefront cabin in the woods. On Tucker's advice, Dale tries to talk to Allison, but his appearance and nervous behavior frighten her and her friends. While Tucker and Dale repair their cabin, Chad tells the group about the "Memorial Day Massacre", a hillbilly attack that took place 20 years prior. They later go skinny-dipping at a lake where Tucker and Dale are fishing. Startled by the pair, Allison hits her head. The hillbillies save her from drowning, but the others run off, believing they are kidnapping her. The next day, Allison awakens at Tucker and Dale's cabin. Initially frightened, she gradually befriends them. Concurrently, Chuck leaves to get the police while Chad leads the others in heading to the cabin to save Allison from the hillbillies. They arrive as Tucker unknowingly hits a beehive while cutting wood, causing him to wildly swing his chainsaw. Believing he is attacking them, the group scatters, and Mitch accidentally impales himself on a fallen tree branch. After finding Mitch's body and concluding he was murdered, Chad persuades the others that they are in a battle for survival. They return to the cabin, where they misinterpret Allison and Dale digging an outhouse hole as her digging her own grave and attack. However, Todd impales himself on a spear he brought, Mike dives into a wood chipper while attempting to tackle Tucker, and Allison gets knocked out by Dale's shovel. As Dale takes her inside, Tucker assumes the group are part of a
suicide pact and dissuades Dale from calling the police for fear that they will be accused of murder. Before long, Chuck returns with Sheriff Gurr, who expresses doubt over Tucker and Dale's theory before accidentally killing himself with a loose beam. Chuck grabs Gurr's gun, but accidentally shoots himself with it. Chad returns, taking Dale's dog Jangers hostage. Tucker rescues Jangers, but gets captured by Chad, who tortures him and cuts off two of his fingers to lure out Dale. Dale leaves to save Tucker while Chad and Naomi try to rescue Allison. She explains what happened, but they accuse her of having
Stockholm syndrome. Tucker and Dale return and Allison leads everyone in a calm discussion, during which Chad reveals his grandmother told him his father died in the Memorial Day Massacre while his mother was the sole survivor. Jason and Chloe break in to save Allison, but Chad accidentally sets Jason on fire, and Chloe tries to put the fire out by unknowingly throwing an accelerant on him. In the ensuing chaos, Tucker, Dale, and Allison escape; Naomi, Chloe, and Jason are killed; and Chad is injured, disfigured, and becomes mentally unhinged. The trio try to escape in the hillbillies' truck, but crash. An injured Tucker tells Dale that Chad took Allison, and Dale must go save her. Jangers leads Dale to an old
sawmill, where Chad threatens to kill Allison for "[going] hillbilly" unless she becomes his girlfriend. However, Dale arrives and rescues her. While barricading themselves upstairs, they find newspaper clippings revealing Chad's father was responsible for the Memorial Day Massacre, which makes Chad "half hillbilly." While Chad is distracted by the revelation, Dale throws a box of chamomile tea at him, causing him to have an asthma attack and fall out of a window to his apparent death. Three days later, a two-person news crew reports from the cabin that the deaths appear to be part of a suicide pact involving a deranged killer, Chad, whose body is yet to be found. This brings the story full circle with the pre-opening title
found footage of Chad killing the news crew. Elsewhere, Tucker convalesces at a hospital while Dale goes bowling with Allison. While there, Dale encourages a fellow hillbilly to talk to some girls, leading to a new misunderstanding while Dale and Allison confess their feelings for each other and kiss. ==Cast==