Freshman season Reese entered her freshman season in the starting lineup for Maryland, primarily as a
power forward. Despite being a freshman, she was praised by head coach Brenda Frese for her leadership. Frese viewed Reese as part of the team's Big Three that also included
Ashley Owusu and
Diamond Miller. In her fourth game, on December 3 against
Towson, she suffered a
Jones fracture in her right foot after landing awkwardly during the opening minutes. She underwent surgery and was sidelined until February 23, 2021. Reese came off the bench following her return from injury. At the end of the regular season, she was named to the Big Ten All-Freshman Team. On March 24, 2021, in the second round of the
NCAA tournament, Reese scored 19 points to help second-seeded Maryland defeat seventh-seeded
Alabama, 100–64. In the Sweet 16, her team was upset by sixth-seeded
Texas, 64–61. As a freshman, Reese averaged ten points and six rebounds per game. Following the season, she won a silver medal with the Maryland
3x3 team at the
USA Basketball 3X Nationals.
Sophomore season in 2022|alt=Reese playing for Maryland Reese returned to a starting role in her sophomore season. She described the season as a "redemption year" and regained confidence from before her injury as a freshman. In her season debut on November 9, Reese recorded 21 points and 14 rebounds in a 97–67 win against
Longwood. On December 2, 2021, Reese had a season-high 26 points and 15 rebounds in an 82–74 win against
Miami (Florida) in the
ACC–Big Ten Challenge. On February 14, 2022, she posted 25 points and 13 rebounds in an 81–69 victory over
Iowa. Reese was named first-team All-Big Ten and made the conference's All-Defensive Team. She led fourth-seeded Maryland to the Sweet 16 of the
2022 NCAA tournament, where she recorded 25 points, 9 rebounds, 3 steals and 3 blocks in a 72–66 loss to first-seeded
Stanford on March 25. Reese received third-team
All-American honors from the AP and made the
United States Basketball Writers Association (USBWA) and
Women's Basketball Coaches Association (WBCA) All-American honorable mention. As a sophomore, she averaged 17.8 points and 10.6 rebounds per game, becoming the first Maryland player to average a
double-double since Angie Scott in 1975. On April 5, 2022, Reese entered the
transfer portal with several of her teammates. She later explained that she wanted a fresh start and a coach who would develop her into a
stretch four to prepare her for the WNBA. She took interest in LSU after
Ohio State transfer Kateri Poole, whom she had known since high school, suggested that they visit the school together. She made the decision due to her trust in head coach
Kim Mulkey and a desire to join a "winning culture". Reese posted 32 points and 15 rebounds in an 88–42 victory over
Lamar on December 14. She surpassed LSU's single-game rebounding record, held by
Maree Jackson since 1977, during a 26-point, 28-rebound performance in a 74–34 win over
Texas A&M on January 5, 2023. Reese had her 20th straight double-double on January 23, with 14 points and 14 rebounds in an 89–51 win against
Alabama. She broke the program record for consecutive double-doubles, set by
Sylvia Fowles during the 2006–07 season. On February 16, Reese had a career-high 36 points and 20 rebounds in a 69–60 win over
Ole Miss. She earned first-team All-
Southeastern Conference (SEC) and All-Defensive Team honors at the end of the regular season. In the first round of the
2023 NCAA tournament, she recorded 34 points and 15 rebounds in a 73–50 win against
Hawaii. Reese posted 25 points, 24 rebounds and 6 blocks in a 66–42 second-round win over
Michigan. In the Elite Eight, she registered her 32nd double-double, breaking the SEC single-season record held by
Teaira McCowan of
Mississippi State. Reese was named Most Outstanding Player (MOP) of the Greenville Regional 2. In the Final Four, she set the program and SEC single-season rebounding records after posting 24 points and 12 rebounds in a 79–72 win over
Virginia Tech. and First Lady
Jill Biden during her team's visit to the
White House in 2023|alt=Reese posing with Joe Biden and Jill Biden, who are both holding LSU jerseys, during her team's White House visit in 2023 Reese helped LSU win its first national championship, posting 15 points, 10 rebounds, and five assists in a 102–85 victory over
Iowa in the
title game. She won the tournament
Most Outstanding Player award and set the NCAA single-season record with 34 double-doubles. In the closing minutes of the game, Reese followed Iowa star
Caitlin Clark around the court and made a "
you can't see me" gesture by waving her hand in front of her face—a taunt popularized by professional wrestler
John Cena—before pointing to her ring finger in reference to a
championship ring. Her actions came under scrutiny, with some journalists and analysts criticizing her for poor sportsmanship and others, including Reese herself, pointing to a
double standard, because Clark had not received similar backlash for making the "you can't see me" gesture two games earlier. Clark later defended Reese from criticism over the gesture. The incident drew attention to the roles of race and gender in the perception of
trash talk in sports since Reese is Black and Clark is white. It has also been described as the origin of a
rivalry between Reese and Clark. Following the game,
First Lady Jill Biden remarked that she wanted Iowa to be invited to the
White House along with LSU, as an addition to the custom of the
president and first lady hosting the national champions. Despite Biden's press secretary clarifying that only LSU would be invited, Reese initially declined the invitation, saying she would prefer to celebrate with the
Obamas, before accepting it with her team later that week. President
Joe Biden called Reese individually to congratulate her on LSU's victory. Reese was a unanimous first-team All-American: she earned first-team All-American honors from the AP and the USBWA, and made the WBCA Coaches' All-America Team. As a junior, she averaged 23 points and 15.4 rebounds per game, becoming the first women's player in over 15 seasons to reach those marks. Reese led the
NCAA Division I in total rebounds and offensive rebounds per game and ranked second to Lauren Gustin of
BYU in rebounds per game. Her 240
free throws made marked an SEC record, and she scored 830 points, the third-most in LSU history. After the season, she won the
BET Award for Sportswoman of the Year and the
Best Breakthrough Athlete ESPY Award. She received the Corbett Award as the top female amateur athlete in Louisiana. LSU was ranked number one by the AP in its preseason
poll, with incoming transfers
Hailey Van Lith and
Aneesah Morrow. On November 6, 2023, Reese recorded 15 points and 12 rebounds in her season debut, as her team suffered an upset loss to AP No. 20
Colorado, 92–78. On November 14, 2023, she had 11 points and five rebounds in a 109–79 win over
Kent State but was benched for the second half, which Mulkey described as a coach's decision and did not elaborate. Reese did not play in LSU's next four games for undisclosed reasons. Mulkey later attributed Reese's absence to locker room issues. On November 30, Reese returned, posting 19 points and nine rebounds in an 82–64 win over AP No. 9
Virginia Tech. On December 19, she shared
Sporting News Athlete of the Year honors with Caitlin Clark. At the end of the regular season, Reese was named
SEC Player of the Year while earning first-team All-SEC and All-Defensive Team recognition from the league's coaches. She led LSU to the Elite Eight of the
2024 NCAA tournament, where she had 17 points and 20 rebounds in a 94–87 loss to one-seed Iowa in a rematch of the 2023 national championship game. For her second straight season, Reese was named a first-team All-American by the USBWA and a WBCA Coaches' All-American. She earned second-team All-American honors from the AP. Reese averaged 18.6 points and 13.4 rebounds per game as a senior, ranking second to Lauren Gustin in rebounding among Division I players. During two years at LSU, she averaged 14.4 rebounds per game, the most in SEC history. On April 3, 2024, Reese declared for the
2024 WNBA draft, where she was projected to be a first-round pick. ==Professional career==