Santoro has stated that, prior to performing in pornographic films, he received a degree in business from the
University of Pittsburgh. He was a one-time resident of
Washington, D.C., where he was a bartender and the general manager of the EFN Lounge and Motley Bar. One year before becoming a pornographic actor, Santoro started dating fellow gay pornographic actor Seth Santoro, who previously went by the name Seth Treston, and the two later got married in 2013. The two divorced in 2017 and Seth alleged later that year on social media that Billy had been physically abusive toward him. In 2014,
Str8UpGayPorn called Santoro "one of today's most in-demand, mainstream gay porn stars". Garridan P. Faxton of
Fleshbot called Santoro "the hardest-working man in skin-business" in 2015 for his consistent appearances in new pornographic films.
AVN called him one of "the industry's hottest performers" in 2017. Santoro tweeted in March 2019 that he would not film pornographic videos with "someone [he had] filmed with in the past" who had "gotten fat" and that he was "not a fan of looking at [their] fat body rolling around all over Twitter", which his Twitter followers criticized as
fatphobic. He called detractors of the tweet "
snowflakes". Until 2020, Santoro and his husband Gage Santoro filmed pornographic videos for their
OnlyFans accounts at their apartment on
Oxford Street in
Sydney,
Australia during the
COVID-19 pandemic, where the police were called on them by neighbors at least three times for failing to
social distance. The
strata committee of their building unanimously voted to evict them in December 2020 for breaking a
noise regulation by-law.
Racist tweets and faked suicide attempt In response to the
George Floyd protests, Santoro made a post on his
Facebook account in June 2020 in which he wrote that "America... let [its] blacks loot as a way of protest" and encouraged police officers to "shoot first". The post led to social media backlash against Santoro, who claimed in response to it that he had "lashed out full of emotional stress" due to the killing of his friend during looting in Philadelphia. Social media users then circulated other posts by Santoro, one in which he claimed that he had not experienced
gay bashing from any "white, redneck Trump supporter" but had from "African American men who live in
Shaw in DC", and another in which he responded to a restaurant's pro-
Black Lives Matter tweet about being able to replace their property if it was destroyed during protests by tweeting that "the blacks will just breed more hatred towards them". Santoro's posts were widely criticized by social media users—including fellow gay pornographic actor
Austin Wolf—as racist and his pornographic account on the subscription-based platform JustForFans was soon taken down by the company, who tweeted that what he wrote was "vile". His OnlyFans account was also deleted and he deleted his personal Twitter account. He then created a new joint Twitter account with his husband, gay pornographic actor Gage, who posted photos of Santoro sitting in a hospital bed and claimed that he had attempted suicide over the backlash. Later that month, he variously claimed that JustForFans, gay
sex toy company Fort Troff, gay pornographic studio Dominic Ford, and underwear company JJ Malibu were all continuing to support and affiliate themselves with him, to which they each responded on Twitter and stated that they had cut ties with him. In October 2020, Santoro posted a video on Twitter, claiming that his posts had been made under the influence of
meth. Santoro admitted in December of that year that he had not actually attempted suicide and that he had actually been in the hospital to get an
ingrown hair removed. In December 2020, Samantha Hutchinson and Stephen Brook of
The Sydney Morning Herald wrote that Santoro and his husband "had gained international notoriety due to racist social comments they blamed on a meth addiction". ==Awards and nominations==