Orlando Pride (2016–2019) In January 2016, Weatherholt was selected by
Orlando Pride in the fourth-round (31st overall pick) of the
2016 NWSL College Draft. She signed with the club in April 2016. She went on to play 12 appearances her first year at the club. She had her contract option exercised for the 2017 season where she made 19 appearances and scored one goal. She was offered a new contract for the 2018 season. During that season Weatherholt played 23 games for the club, tied for the most in the season for any Orlando Pride player alongside
Shelina Zadorsky. Her contract option was exercised for the 2019 season.
Loan to Melbourne Victory (2018–2019) On October 16, 2018, the
Melbourne Victory announced they had signed Weatherholt on loan for the
2018–2019 W-League season. She made 12 appearances as the team won the Premiership title, marking Weatherholt's first professional trophy.
OL Reign (2020–2021) On January 22, 2020, Weatherholt was traded to
OL Reign in exchange for Reign's natural second-round pick in the 2021 NWSL College Draft.
Angel City FC (2022–2023) Weatherholt was selected by
Angel City FC with the first overall pick the
2022 NWSL Expansion Draft. She made 41 regular season appearances across two seasons in Los Angeles, winning 185 duels, 47 tackles and creating 10 chances.
North Carolina Courage (2024–present) On January 16, 2024,
North Carolina Courage announced they had signed Weatherholt as a free agent to a two-year contract through 2025. Head coach
Sean Nahas deployed her variously at
defensive midfielder,
center back, and
left back, saying: "That's why we brought her here. She is basically a Swiss Army knife". On December 1, 2025, the Courage announced a one-year contract extension for Weatherholt through 2026. ==International career==