Youth career At the age of 11, Van Domselaar started playing
football at LSVV in
Zuid-Scharwoude. In the team that she joined, the girls played without a regular keeper. However, after Van Domselaar took her turn as goalkeeper, she did not leave that position but stayed in it. The LSVV goalkeeping
coach immediately recognised her great talent. Moreover, he noted that she had learned a lot at the volleyball club from which she had come. Van Domselaar then played for four years with the boys of LSVV and for two years with
Telstar's youth academy. In her second year at Telstar, she was the one-off reserve keeper of the senior team in their away match against PSV on 4 February 2017. Telstar continued as
VV Alkmaar in the following season. Soccerway erroneously reports that Van Domselaar played with VV Alkmaar in the 2016–17 season. From the 2019–20 season, Van Domselaar was FC Twente's first-choice goalkeeper. After the
UEFA Women's Euro 2022 championship, various foreign clubs were interested in Van Domselaar, but she decided to stay with FC Twente for the 2022–23 season. She did say that she hoped for a transfer to “a very nice club outside the Netherlands” in 2023. At the end of 2022, she was the only Eredivisie player included in
The Guardian's annual list of the
100 best female football players in the world. On 16 June 2023,
Women's Super League club
Aston Villa announced the signing of Van Domselaar on a three-year deal until 2026. In March 2024, Van Domselaar underwent surgery on her hip, and would miss the remainder of the WSL season. On 31 July 2024, it was announced that
Arsenal had signed Van Domselaar after triggering a substantial buyout clause in her Villa contract. On 9 March 2025, Arsenal were knocked out of the FA Cup quarterfinals against Liverpool, after an unfortunate own goal from Van Domselaar. After suffering a concussion from the FA cup match against Liverpool Van Domselaar missed Arsenal’s next two matches. She returned to the squad against Liverpool in their league match, keeping a clean sheet in a 4-0 Arsenal win. ==International career==