Vescio was signed as a marquee player by in July 2016, ahead of the league's inaugural 2017 season. They made their debut in round 1,
2017, in the club and the league's inaugural match at
IKON Park against . They kicked a game-high four goals in the match, which was more than Collingwood's overall team score. This was acknowledged by the
AFL Players Association, highlighting Vescio as Player of the Week. At the conclusion of the 2017 season, Vescio was the AFLW leading goalkicker, was nominated by their teammates for the AFLW Players’ Most Valuable Player Award, and was listed in the 2017 All-Australian team. Their mark in front of goal in round five against was voted by fans as Mark of the Year. They played in all seven of Carlton's matches that season and kicked five goals, tying
Tayla Harris and sharing the club's leading goalkicker award with her. For the 2019 season, Vescio was elevated to the leadership group alongside
Shae Audley,
Kerryn Harrington and
Sarah Hosking, with
Bri Davey serving as captain and
Katie Loynes as vice-captain. They signed a two-year contract with on 10 June 2021, after it was revealed the team had conducted a mass re-signing of 13 players. Vescio was awarded with their second
All-Australian blazer, named on the interchange bench. Vescio achieved selection in Champion Data's 2021 AFLW All-Star stats team, after leading the league for goals in the
2021 AFL Women's season, totalling 1.8 a game. ==Statistics==