Davao City to Digos . This section forms part of N916-5. Starting at the Bonifacio Rotunda in the Davao City proper, the Davao–Cotabato Road begins as the western section of National Route 916-5 (N916-5) and a component of the
Pan-Philippine Highway (AH26). It initially runs northwest as A. Pichon Street, a one-way street carrying southeast-bound traffic. The route then turns southwest onto Elpidio Quirino Avenue and becomes MacArthur Highway upon crossing the General Generoso Bridge I over the Davao River. It then meets
Carlos P. Garcia National Highway, where it turns west and becomes part of National Route 1 (N1). It then enters
Santa Cruz, Davao del Sur as it traverses its eastern coast. It enters Digos and there it meets Digos–Makar Road, locally known as Rizal Avenue, where N1/AH26 would continue.
Digos to Makilala . N75 commences at the intersection with N1/AH26. It traverses to the west through the municipality of Bansalan onto towards Makilala for . There is a gateway sign when entering Makilala.
Makilala to Matalam . At Makilala, it connects towards
Makilala–Allah Valley Road (N76) which links Makilala to Sultan Kudarat Province. It traverses Kidapawan, where it is locally known as Quezon Boulevard, and connects to Paco–Roxas–Arakan Valley–Junction Davao–Bukidnon Road (N942). The route then traverses into Matalam for . There is a roundabout that connects Davao–Cotabato Road to a national tertiary highway that leads to M'lang and a shortcut for Makilala–Allah Valley Road (N76).
Matalam to Kabacan Davao–Cotabato Road traverses towards Kabacan and has a crossing that links up with
Sayre Highway (
N943). It connects North Cotabato to Bukidnon. The total length of this section is at .
Kabacan to Midsayap At Kabacan, the Davao–Cotabato Road traverses towards Maguindanao del Sur into Datu Montawal and Pagalungan. It then enters Cotabato, traversing Pikit and Aleosan onto towards Midsayap for . At Midsayap, it links to N940 that traverses towards Marbel.
Midsayap to Sultan Kudarat, Maguindanao del Norte N75 traverses towards into Libungan and links up with Banisilan–Guiling–Alamada–Libungan Road (N944). It finally traverses towards Pigcawayan and Sultan Kudarat into its western section. The western section of Davao–Cotabato Road (N75) links back into the Pan-Philippine Highway in . == History ==