O'Brien was selected in the first round with the fourth overall pick of the
1939 NFL draft, held in December 1938. He was selected by the
Philadelphia Eagles, and owner
Bert Bell gave him a $12,000 bonus and a two-year contract, and he signed with the team in March. O'Brien became the first Heisman trophy winner to play in the NFL. of the Lions after delivering a pass, 1940. In his rookie season in the NFL in
1939, O'Brien led the league in passing with 1,324 yards in 11 games, breaking his old TCU teammate Sammy Baugh's single season passing yardage record, but the Eagles finished at 1–9–1. After an
appendectomy in late June, he again led the league in several passing categories in
1940, including attempts and completions. Despite O'Brien's efforts, Philadelphia lost their first nine games and finished at 1–10, last in the ten-team league. The Eagles offered O'Brien a $2,000 raise for 1941, but he retired after the 1940 season to take a government job. In his professional career, O'Brien completed 223 of 478 passes for 2,614 yards and 11 touchdowns. He was also a
defensive back and
punter,
intercepted four passes for 92 yards and punted nine times for an average of 40.7 yards per kick. ==Life after football==