Moore earned a spot on the 1980 US Olympic Team, but did not compete due to the
US boycott of the Moscow Olympics. One of Moore's early wins was in June 1981 over Kevin Rooney, who would later train Mike Tyson. Moore entered the fight with a 6–0 record, while Rooney was 15–0. Moore won by a TKO in the seventh round of an eight-round fight. After winning eight professional fights, five by knockout, the
WBA named him their No.10 challenger, and in February 1982, he traveled to Japan, where he knocked out defending champion
Tadashi Mihara in six, winning the WBA world junior middleweight title. In April 1982 he defended his world title against
Charlie Weir in Johannesburg, South Africa, taking five rounds to knock him out. Then in July 1982 he fought former world champion
Ayub Kalule, whom he stopped in the tenth round in Moore's second title defense. Moore started 1983 by beating challenger
Gary Guiden, by knockout in the fourth round. He had been scheduled to fight
Tony Ayala Jr., but Ayala was convicted of burglary and rape and sentenced to 35 years in prison. Next, Moore defended against former two-division world champion
Roberto Durán. Moore appeared to be overconfident against an aging 'Hands of Stone' Duran but Duran totally outclassed him and dished out vicious punishment, hammering shut one of Moore's eyes and stopping him in eight brutal rounds at
Madison Square Garden. The beating was so one-sided that Moore's mother and girlfriend were both said to have fainted at ringside. Many knowledgeable observers believed that referee Ernesto Magana should have stopped the fight far earlier. This was proven to be correct by the fact that Moore was never the same fighter after this contest. In 1992,
Colombo crime family Caporegime
Michael Franzese testified that Moore was handled by himself and other Colombo mobsters, and that although they knew that Moore was in poor physical condition because he had undergone oral surgery just 2 days before the fight, they decided to proceed with the fight due to the profitability of betting on Duran. Franzese believed that bribery may have taken place for Moore to pass the physical examination. Moore won his next two fights, the second in
Monte Carlo over
Wilfred Benítez but then he was disqualified in the ninth round against Louis Acaries in Paris. In 1985, he won one more fight and was in line to challenge
Carlos Santos for the
IBF World Junior Middleweight title. That fight did not materialize, but eventually he did get to challenge for the IBF title against
Buster Drayton in August 1986. Moore lost by TKO in the tenth round and only fought 5 more times, winning 3 and losing 2. ==Professional boxing record==