During 1961–1964, Levine served as an Orthopaedic Resident at the Hospital for Special Surgery. In 1965–1966 he served as an orthopaedic spine fellow at the
Rancho Los Amigos Hospital in Downey, California. From 1965 to 1966, he was a spine fellow at the
Los Angeles General Hospital, where he was also an instructor in Orthopedic Surgery at the
University of Southern California. In 1967, he was certified by the
American Board of Orthopaedic Surgery. From 1966 to 1995, Levine was on the attending staff at Hospital for Special Surgery (HSS), as an orthopaedic surgeon. He held the titles of Chief of the Scoliosis Service (1968–1995), and Director of the Department of Orthopedic Surgery (1987–1990). As Chairman of the Orthopedic Residency Training Program (1987–1990), he streamlined the application process, helping to introduce one of the first computerized scoring processes and adding a psychologist interview session. He taught for over thirty years at
Cornell University Medical College, and from 1978 to 1995 held the title of Professor of Clinical Orthopaedic Surgery at the Weill Cornell Medical College. From 1979 to 1982, Dr. Levine was an Alumni Council Trustee of the college. In addition, he was a surgeon at
The New York Hospital, and the
Bronx Veterans Administration Hospital. From 1976 to 1980, he was Visiting Associate Physician at The
Rockefeller University Hospital in New York City. During his career, Levine published over 65 peer reviewed articles, 16 books and chapters and gave more than 300 invited presentations. He was the proposer of the
Scoliosis Research Society in 1964, a founding member and its president from 1978 to 1979, serving on the board of directors for fifteen years. In 2010, the Society, now a highly recognized international organization, presented him with its "Lifetime Achievement Award." In 2006, the hospital announced the creation of The David B. Levine Endowed Clinical Research Chair. ==Historian of medicine and early immunotherapy research==