He returned to Nobleville to help his father in his clinic In 1852, he purchased the Philadelphia School of Anatomy for $600 and taught there for ten years. In 1854, he worked as a surgeon in the Philadelphia General Hospital and founded the pathological museum. After the
Battle of Gettysburg, he traveled to field hospitals near the battlefield and administered care, including to General
Winfield Scott Hancock. This was his first experience with military surgery and an emerging medical field due to the proliferation of gunshot wounds and injuries and diseases due to military activities of the American Civil War. The depth of experience he obtained during the war burnished his reputation as one of the top surgeons in the United States and an expert on gunshot wounds. In 1863, he founded the Philadelphia School of Operative Surgery and worked as a surgeon at Wills Eye Hospital. In 1864, he was appointed surgeon at Pennsylvania Hospital and in 1867, surgeon to Orthopedic Hospital. He served as president of the Philadelphia County Medical Society in 1870, the Pennsylvania State Society in 1877, the Philadelphia Academy of Surgery in 1888, and the American Surgical Association in 1888. He served as manager of the
Philadelphia House of Refuge for thirty-three years and served on the board of directors of the
Philadelphia Dental College and the
Franklin Institute. He was elected president of the College of Physicians of Philadelphia in 1890. He published 100 journal articles and several publications on surgery including
The Principles and Practice of Surgery, which covered his medical experience of fifty years. ==
The Agnew Clinic==