Born in
Cali, Colombia, Murillo began his career with
Categoría Primera A club
Independiente Medellín, making his professional debut on 13 April 2012 in the
Copa Colombia against
Atlético Nacional. He started and played whole first half before being substituted as Independiente Medellín were defeated 2–1. A year later, Murillo moved to
Deportivo Pasto and made his league debut on 4 August 2013 against
Patriotas Boyacá. He was a starter in the 1–1 draw. In 2015, Murillo joined Patriotas Boyacá and made his debut on 7 February 2015 against
Millonarios. He was a starter as Patriotas were defeated 2–0. On 6 April 2017, Murillo made his international club debut in the
Copa Sudamericana against
Everton. He then scored his first professional goal on 3 August 2017 in a Copa Colombia match against
Unión Magdalena. His 80th minute goal was enough to give Patriotas a 1–0 victory. In 2018, Murillo left Patriotas Boyacá and re-joined Independiente Medellín, making his debut on 3 February 2018 against
Atlético Huila. His scored his first goal for the club in his second match on February 11 against
Boyacá Chicó in a 2–1 victory. A year later, on 7 February 2019, Murillo made his debut in the
Copa Libertadores against
Palestino. On 13 February, during the return leg, Murillo scored the equalizer against Palestino that would eventually lead to penalties which Independiente lost 4–1. In November 2019, Murillo started in both matches for Independiente Medellín against
Deportivo Cali in the finals of the
2019 Copa Colombia. Medellín won the title 4–3 in aggregate, drawing the first leg 2–2 and then winning the second leg 2–1. On 14 October 2020, Murillo joined
Major League Soccer club
Los Angeles FC on loan for the remainder of the
2020 season. On 22 January 2021, Murillo signed with Los Angeles FC on a permanent transfer from Independiente Medellín. On 27 November 2024, Los Angeles FC announced that Murillo's contract with the club had ended and that the club were in talks to retain him. On 27 December 2024,
Liga MX club
FC Juárez announced they had signed Murillo to the club for the
2025 season. ==Career statistics==