They were signed in late 1964 by
Jerry Wexler to
Atlantic Records, with an agreement that allowed them to record in Memphis with
Stax Records. Their first two singles failed to chart, but the duo's November 1965 single, "You Don't Know Like I Know," started a series of ten straight top twenty
Billboard R&B hits, including "Hold On, I'm Comin'" (1966), "You Got Me Hummin'" (1966), "When Something Is Wrong with My Baby" (1967), "Soul Man" (1967), and "I Thank You" (1968). Starting with "Hold On, I'm Comin'", Moore was typically given the lead vocal (first verse and lead voice in chorus) on most of their recordings. Prater sang the tenor lead first verse on their only ballad to become a hit single, "When Something Is Wrong with My Baby", demonstrating an impressive vocal range in the upper register. Their biggest hits were written and produced by
Isaac Hayes and
David Porter, who worked as songwriters for Stax. Sam & Dave's Stax records also had from the backing of the Stax house band,
Booker T. & the M.G.'s, and the Stax horn section,
The Mar-Keys. These musicians co-wrote (often without credit) and contributed greatly to the recordings. Sam & Dave's Stax recordings through 1967 were engineered by Stax founder and co-owner Jim Stewart, who created the "
Memphis sound" at Stax by recording sessions in a single take. The combination of all of these contributed to the sound and commercial success of Sam & Dave's Stax recordings. ==Atlantic years, solo career, and back with Sam and Dave (1968–1981)==