Pryor first won elected office representing Ouachita County in the
Arkansas House of Representatives in 1960. Seated as a member of the
63rd Arkansas General Assembly, Pryor would win reelection to the seat in 1962 and 1964. In 1966, Pryor was elected to Congress following a vacancy that year after
U.S. President Lyndon B. Johnson appointed fellow Democrat
Oren Harris to a federal judgeship. He was not a candidate for reelection in 1972, instead challenging longtime U.S. Senator
John L. McLellan in the Democratic Primary. Pryor lost to McLellan in a runoff by less than 20,000 votes. Pryor entered the 1974 Democratic Gubernatorial Primary when Governor
Dale Bumpers declined a third term to successfully challenge Senator
J. William Fulbright. Pryor narrowly avoided a runoff in the primary, defeating former governor
Orval Faubus and Lt. Governor
Bob C. Riley, then easily besting Arkansas Republican Party Executive Director
Ken Coon in the General Election. Pryor was reelected in 1976, gaining 66 percent of the vote in the Democratic Primary against former Razorback football great
Jim Lindsey, and 86 percent in November against a token Republican. He served as Governor of Arkansas from January 14, 1975 to January 3, 1979. Navigating a difficult economy from the 1974–76 recession, Pryor appointed banker and future governor
Frank D. White as his economic development director. He declined a third term in order to seek McLellan's former seat in 1978 (the senator died in 1977) and faced two congressmen:
Jim Guy Tucker and
Ray Thornton in the Democratic Primary. Pryor advanced to a runoff with Tucker, and defeated the central Arkansas congressman by 12 points. He defeated a Republican and Independent opponents in the General Election with 76 percent of the vote. In 1984, in spite of the
Ronald Reagan landslide, Pryor defeated central Arkansas Congressman
Ed Bethune in a race dominated by national GOP money backing Bethune. In 1990, Pryor defeated a write-in candidate; no other Democrat or Republican filed. He retired in 1996 and was replaced by Republican congressman
Tim Hutchinson.
U.S. Senate Pryor served as chairman of the
Committee on Aging. Pryor was known for his advocacy for the aged and for promoting taxpayer rights. During his tenure, he was secretary of the Democratic Conference, third in the Senate Democratic Leadership. In 2000, Pryor became Director of the Institute of Politics at
Harvard Kennedy School in
Cambridge, Massachusetts. He served as
dean of the
Clinton School of Public Service in
Little Rock from 2004 to 2006. In June 2006, President
George W. Bush nominated Pryor to the board of the
Corporation for Public Broadcasting, and in September of that year he was confirmed by the Senate for a six-year term. As he had done occasionally in the past, Pryor taught a
political science course at the University of Arkansas in Fayetteville during the Fall 2008 term. ==Post-Senate career==