David Spence may refer to:David Spence (VC) (1818–1877), Scottish recipient of the Victoria Cross David Spence (1867–1940), member of the Canadian House of Commons Dave Spence, candidate for governor in Missouri David Spence (1824–1885), politician in Manitoba, Canada David Spence (mathematician) (1926–2003), New Zealand and British mathematician David Spence (1881–1957), pioneer in the field of rubber chemistry Dave Spence (cricketer), New Zealand cricketer David Jerome Spence (1873–1955), Canadian architect, designer of such buildings as Montreal's Martlet House David H. N. Spence (1925-1985) British botanist