Cesena Biondini started his career at
Cesena, near his birthplace. After playing more than 40
Serie C1 games, he left the club.
Vicenza Biondini was transferred to Serie B team
Vicenza Calcio in temporary deal in 2003. in 2004 the Veneto club acquired Biondini in
co-ownership deal for €250,000. In June 2005 Vicenza acquired Biondini outright after winning the bid mediated by Lega Calcio for €202,500.
Reggina In August 2005 Biondini was signed by Serie A club
Reggina Calcio in another co-ownership deal for €500,000, which the Calabria team also signed
Luca Rigoni from Veneto, with
Ricardo Esteves moved to opposite direction. Biondini made his Serie A debut in
2005–06 Serie A. Circa January 2006 Reggina signed Biondini outright for another €700,000, with
Simone Cavalli moved to opposite direction outright for €775,000. In 2007 Cagliari excised the option.
Genoa On 11 January 2012, he left for
Genoa on free transfer in -year contract.) After a single season, signed a loan deal with the newly promoted Serie A club
Atalanta on 24 August 2012 for €200,000.
Sassuolo On 23 January 2014, Biondini left for
Sassuolo in a temporary deal for €200,000, with an option to purchase, re-joining Genoa teammate
Antonio Floro Flores (loan) and
Thomas Manfredini (definitive). In June 2014 Sassuolo excised the options to purchase Biondini and Floro Flores from Genoa, for €1.3 million Following Cesena's promotion back to
Serie C at the end of the 2018–19 season, he retired from playing. ==International career==