2005–2011 On 1 February 2005,
Mustin began her maiden deployment and returned on 1 August. In July 2006,
Mustin and her crew of 300 were deployed to
Yokosuka Naval Base in Japan, home of the Navy's
Seventh Fleet, for permanent assignment. Though this was during the same month as the
North Korea missile tests, the deployment was unrelated. During the 2008
Cyclone Nargis crisis in Myanmar and the subsequent
Joint Task Force Caring Response aid mission,
Mustin, then as part of the Amphibious Ready Group (ARG), which including and , stood by off
Burma from 13 May to 5 June, waiting for the
Myanmar junta government to permit US aid to its citizens. However, in early June, with permission still not forthcoming, it was decided to return the ARG to its scheduled operations. In March 2011, in company with aircraft carrier ,
Mustin was deployed off northeastern
Honshu, Japan. The mission was to assist with relief efforts after the
2011 Tōhoku earthquake and tsunami. During the
2011 Thailand floods,
Mustin was docked at Port
Laem Chabang on a routine visit when the Thai government requested the warship to prolong her stay for up to six days to provide aerial surveillance of the flooding. In response,
The Pentagon gave permission for the two
Seahawk helicopters, from
HSL-51 detachment Six, to provide the imaging. On 19 December 2020,
Mustin transited the contested
Taiwan Strait, which the US Navy said was "in accordance with international law" to "demonstrate the US commitment to a free and open Indo-Pacific." In Spring 2021,
Mustin monitored after the latter sailed through the
Miyako Strait, along with alleged Chinese militia boats amassed near
Whitsun Reef in the Philippines.
Liaoning entered the Philippine Sea immediately after the
Whitsun Reef incident. On 4 April,
Mustin approached
Liaoning, maneuvred between her and her escorts, and photographed the commanding officer relaxing with his feet up, next to the executive officer with his arms crossed.
Mustin was accused of "
cognitive warfare" and was called "very vile." A quote from one media outlet described the incident as such; "There are some photos that come to define the beginning of an era, and the
Mustin photo has that feel. It perfectly encapsulates this moment in time as the US Navy, and the rest of the western world, looks on as China's military continues its meteoric rise.
Liaoning, China's first carrier, is an excellent example of that." Later, Vice Admiral
Roy Kitchener claimed the photo was evidence that the carrier had "operating restrictions" with her escorts which allowed the US warship to get so close. After completing a homeport shift from Yokosuka in July 2021, she is now part of
Destroyer Squadron 1, based at
San Diego, California. The ship is expected to shift its homeport to Yokosuka again from San Diego in 2026, replacing
USS Robert Smalls. The
Mustin is the first Arleigh Burke-class destroyer to receive the Mk 38 Mod 4 and conducted a live fire exercise in the
South China Sea on April 17, 2026. ==Awards==