In September 2021, Frank West, a former photojournalist now working as a college professor, is approached by one of his students, Vicky "Vick" Chu, who convinces him to help her investigate a military compound, situated on the outskirts of Willamette,
Colorado — the site of the
second zombie outbreak. Once inside, they find out the compound is being used for zombie research, but are discovered and forced to flee, with Frank labelled a fugitive after he is falsely accused by the government. Four months later in 2022, after Christmas, Frank is found by Brad Park, an agent of the ZDC, who convinces him to help investigate a new zombie outbreak in Willamette during the Black Friday sales, in exchange for the means to clear his name and having exclusive rights to the story, revealing Vick has already left to investigate the matter herself. Just as they arrive at Willamette, Frank and Brad's helicopter is hit by a missile, forcing them to make a crash landing in the middle of the shopping mall. Upon confronting the zombies, they are discovered to be infected with a new, more aggressive strain of the parasite that previous treatments like Zombrex are ineffective against. Frank eventually discovers an elusive organization called "Obscuris" is in the city looking for a monstrous creature called "Calder", and reunites with Vick on a few occasions, but their opposing views prevent them from working together. Frank manages to approach an Obscuris truck carrying Calder, but it drives off, leaving him to confront an Obscuris lieutenant. Upon investigating the laboratory of Dr. Russell Barnaby, the main scientist behind the zombie outbreak in Santa Cabeza,
Central America, Frank learns that during his last days, Barnaby was developing ways to make zombies with their human intelligence intact before Carlito lured him to the Willamette Parkview Mall, resulting in his death. Calder was once a human Obscuris soldier enhanced with a military
exoskeleton transformed by accident into an intelligent but violently psychotic zombie-like mutant, who downloaded Barnaby's data on a disk he always carries on his person. Frank finds himself having to confront Calder in order to retrieve it. Frank later invades the base of Obscuris and faces the leader of the organization, Fontana - and the one responsible for bringing down the helicopter carrying him and Brad. Fontana reveals their group was not responsible for the outbreak. Instead they were hired by an unknown client to obtain Calder's data, seeking to use the research on intelligent zombies to make cheap labor for factories and plantations in developing countries. Their confrontation is interrupted by Calder, who kills Fontana. After rescuing several survivors from a group of psychotic survivalists, Frank pursues Calder down to the sewers, where he steals the disk and transfers the data to his camera. Vick appears with a gun, forces Frank to give her his camera, and flees after destroying the disk. Frank runs after her all the way to the shopping mall where they are intercepted by Calder, who destroys the camera, and the two work together to kill him. After the battle, Vick reveals to Frank she took the camera's SD card, containing all of the disk's data, and they reconcile, agreeing to share the credit for the story. Frank, Vick and Brad leave for the rooftop to be extracted via helicopter, but a massive horde of zombies pursue them on the way there. Brad and Vick make it to the helicopter, but Frank is grabbed as he is boarding and, unable to break free from their grip, sacrifices himself so Vick and Brad can escape.
Frank Rising In this downloadable content released in April 2017, Frank, after falling from the helicopter, is half eaten by the zombies, but suddenly after all the zombies have gone away, the experimental wasps infect Frank, converting him into an evo zombie. This gives him new abilities like acid spit, pouncing, and roaring. After gaining all these new abilities, Frank begins eating humans as well as zombies. In the Willamette Mall, Frank is shot and taken to Barnaby's lab where he is given control of his body back, but loses all of his powers. Dr. Blackburne, the Obscuris scientist who treats Frank, tells him that the military plans to firebomb Willamette. The only way to survive is to get on the evacuation helicopter which would arrive shortly. Blackburne also tells Frank he could regain all his powers by absorbing the wasps present in evo zombies. Frank asks about a cure, which Blackburne agrees to help him with if he gathers supplies for her. Blackburne later double-crosses Frank, but he threatens her into continuing to cooperate. Blackburne explains she needs to get into Barnaby's lab but cannot due to high levels of radiation. Frank is eventually successfully cured back to a human and is able to escape with Blackburne in the evacuation helicopter. If Frank does not collect all special wasps during the game, Frank escapes alone with Blackburne and retires from journalism, spending the rest of life in fear of becoming a zombie again. If he does, Hammond and her team escape with them and Frank becomes famous again, writing a book about his experience as a zombie that becomes a bestseller, and exposes the government's involvement with Obscuris with Vick's help. If the player runs out of time during 'The Cases', the story ends in a failed rescue due to bombardment commanded by the United States Government to prevent the zombie outbreak from spreading throughout the state. ==Development==