8-Hydroxy-5-deazaflavin:NADPH oxidoreductase (EC 1.5.1.40, 8-OH-5dFl:NADPH oxidoreductase) is an enzyme with systematic name reduced coenzyme F420:NADP+ oxidoreductase. This enzyme catalyses the following chemical reactionreduced coenzyme F420 + NADP+ coenzyme F420 + NADPH + H+