In 1997, Matenopoulos was an
MTV production assistant and, after a chance meeting with
Barbara Walters was invited to audition and was cast, at age 22, as the youngest co-host on Walters's new talk show,
The View. In January 2004,
Good Day Live brought in Matenopoulous (along with
Arthel Neville) to co-host the nationally syndicated program. On September 29, 2004, she was hospitalized for an injury that was the result of a stunt she attempted for a segment of
Good Day Live. The segment was focused on firefighter training, in which she practiced a fall from a three-story building at a Los Angeles fire station. She landed incorrectly on an airbag and was rushed to the hospital for a possible head injury. It was a closed head wound and she was temporarily blind. Despite massive promotion, including a mall-tour featuring Matenopoulous and Arthel Neville,
Good Day Live was canceled by its syndicators in March 2005. In January 2006, Matenopoulos joined
E!'s coverage of the
Golden Globe Awards. In April of that same year, she became one of the three hosts on E!'s weeknight celebrity gossip and pop culture series,
The Daily 10, a position she held until August 2009. While at E!, Debbie also hosted
Fashion Police,
Live from the Red Carpet, and the
Style Network's
Instant Beauty Pageant. On July 25, 2006, over seven years after her last appearance on
The View, she was invited back as a special guest co-host for a day, the first of many subsequent guest appearances she has made on the show over the years. Matenopoulos has also been a frequent contributor to
VH1 specials, including
I Love the 90s and
I Love Toys. She has also been a guest judge on
''RuPaul's Drag Race 3''. Debbie's first
cookbook,
It’s All Greek to Me, was released in the spring 2014. A revised
paperback edition was released in 2018. On July 6, 2015, Matenopoulos was named the co-host of
The Insider, a position she held until the show's cancellation on September 9, 2017. Debbie was subsequently named as a Special Correspondent for
Entertainment Tonight. In 2016, while still co-host of
The Insider, Matenopoulos became co-host of
Home & Family, replacing
Cristina Ferrare. == Personal life ==