On the death of Kaikhosro,
Qvarqvare IV, the eldest of his eight children with Dedisimedi, succeeded to the principate of Samtskhe. Since he was still young and inexperienced, the actual government of the country was taken over by Dedisimedi and the nobleman Varaza Shalikashvili, whose sister was a favorite wife in Shah Tahmasp's
harem. Dedisimedi was personally involved in fighting, directing operations at
Queli and Tmogvi. Eventually, the Jaqeli prevailed, but the decimated country became an easy target for the
powerful thrust of the Ottoman army under
Lala Kara Mustafa Pasha's command in August 1578. The nobles of Samtskhe submitted after a token resistance and Lala Pasha made a common cause with Dedisimedi's more able and calculating son
Manuchar, a co-regent with his mother. The Jaqeli accepted Ottoman suzerainty. Lala Pasha met Dedisimedi at her base at
Okros Tsikhe (Altunkal'a) and politely made it clear that her elder sons should become Muslims. In 1579, both Qvarqvare and Manuchar repaired to
Constantinople and the latter pompously converted to Islam under the name of Mustafa. Following Qvarqvare's death in 1581, Manuchar-Mustafa became an Ottoman governor of a reduced Samtskhe, that is,
pasha of Childir. Dedisimedi left the Ottoman-occupied Samtskhe in 1585 and retired to Akhaldaba, in Kartli, where Manuchar, having revolted from the Ottoman authority, had also taken refuge. Early in 1586, Manuchar acceded to the Ottoman demands and sent Dedisimedi and her grandson, Kaikhosro's son, to Samtskhe. Thereafter, she disappears from the contemporary historical records, save for the Ottoman fiscal documents of 1595, listing the estates formerly belonging to her in Samtskhe. == Children ==