DE 6 begins at the
Maryland border, where the road continues west into that state as
MD 291. From the state line, the route heads east on two-lane undivided Millington Road, passing through the Blackiston Wildlife Area. The road runs through areas of woods and farms with some homes. In the community of
Blackiston, DE 6 intersects the western terminus of
DE 42, which heads southeast toward the town of
Kenton, and Longridge Road. The route continues east through more agricultural areas and reaches a junction with
DE 15, at which point residential development near the road increases. DE 15 turns east to form a
concurrency with DE 6. Upon reaching the western edge of the town of
Clayton, DE 15 splits from DE 6 by heading to the north. DE 6 proceeds northeast through Clayton on Main Street, where it passes homes along with a few businesses. In Clayton, the road crosses the
Delmarva Central Railroad's Delmarva Subdivision line at-grade north of the former
Clayton Railroad Station as it turns more to the east. The route continues into the town of
Smyrna, where it becomes Smyrna Clayton Boulevard. Shortly after entering Smyrna, DE 6 crosses
Greens Branch and intersects
DE 300, where it turns northeast onto West Glenwood Avenue and forms a concurrency with DE 300. The two routes pass a mix of homes and businesses before gaining a
center left-turn lane past the Main Street junction and entering a commercial area in the northern part of Smyrna as East Glenwood Avenue. Here, the road widens into a
divided highway before intersecting
US 13. At this point, DE 300 ends and DE 6 turns southeast to form a concurrency with US 13. The two routes pass more businesses on four-lane divided North Dupont Boulevard. DE 6 splits from US 13 by heading to the east on two-lane undivided East Commerce Street, running through residential areas. The route passes over the
DE 1 toll road without an interchange and leaves Smyrna. DE 6 has an
annual average daily traffic count ranging from a high of 26,210 vehicles at the east end of the US 13 concurrency to a low of 525 vehicles at the Delaware Avenue intersection in Woodland Beach. ==History==