After working for a short time with the
Dupont Company, he became a lecturer at
Cornell University, followed by an eight-year stint at the
University of South Carolina (where he helped form their first Ph.D. degree program in chemistry). In 1961 he joined the chemistry department at
Florida State University, where he remained until retiring in 1988. During his career, DeTar wrote or co-authored 498 peer-reviewed publications in the areas of
physical organic chemistry and
computational chemistry between 1941 and 2007. His most cited papers were focused on reaction mechanisms and the properties of conformationally flexible molecules. In 1976, he became the founding editor of the journal Computers and Chemistry (now known as
Computational Biology and Chemistry). Although DeTar retired his faculty position and was given the title of Professor Emeritus in 1988, he was prolific in retirement and subsequently published 95 more papers; his last was published in 2007, in
the Journal of Physical Chemistry A. ==Awards and honors==