The protein encoded by this gene is one of the four known components of the
sarcoglycan complex, which is a subcomplex of the
dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. The mutations in this gene have been associated with autosomal recessive
limb-girdle muscular dystrophy and
dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed. == Interactions ==