All mambas have
medically significant venom, with
dendrotoxins, short chain
alpha-neurotoxins,
cardiotoxins and
fasciculins. All mambas are classified as snakes of medical importance by the
World Health Organization. There are multiple components in dendrotoxins with different targets: •
Dendrotoxin 1, which inhibits the K+ channels at the pre and post-synaptic level in the intestinal smooth muscle. It also inhibits Ca2+-sensitive K+ channels from rat skeletal muscle‚ incorporated into planar bilayers (Kd = 90 nM in 50 mM KCl).) •
Dendrotoxin 3, which inhibits
acetylcholine M4 receptors. •
Dendrotoxin 7, commonly referred to as
muscarinic toxin 7 (MT7) inhibits acetylcholine
M1 receptors. with activity as a selective blocker of voltage-gated potassium channels Toxicity alone does not determine severity of
envenomation; other factors include the snake's temperament, venom yields, proximity of wounds to the
CNS and depth of punctures. Bites by all members of this genus are capable of causing rapid onsets of symptoms, but it is the black mamba whose
bite has the worst prognosis, possibly as a result of its more terrestrial nature (having more potential for human contact), high defensiveness (having a higher possibility to deliver fatal bites instead of
dry bites), large size (giving it a higher strike position proximal to the victim's
brain), and higher average venom yields and potential toxicity (based on
experimental results). A lethality rate of near 100% for untreated black mamba bites has been circulating between various sources, Since then, the number has significantly dropped with the widespread use of specific antivenom. Despite their fearsome reputation and often exaggerated notoriety, mamba envenomation occurs far less frequently than some other snakes', for instance the
puff adder. Besides proximity to residences, behaviour of a given species is also a critical aspect when it comes to snakebite morbidities. Mambas are agile, usually fleeing from any confrontation with unambiguous
threat display which allows early recognition of the serpent, avoiding escalation in tension. ==Taxonomy==