Deoxyuridine monophosphate (dUMP) is the deoxygenated form of
uridine monophosphate (UMP), and is the precursor to deoxythymidine monophosphate (dTMP), a component of DNA
nucleotide biosynthesis. By replacing the
hydroxyl group at the 2' carbon of ribose with a hydrogen, UMP becomes deoxygenated to dUMP. The synthesis of deoxyuridine monophosphate (dUMP) is a multi-step process that begins with
uridine monophosphate (UMP), the product of
pyrimidine biosynthesis. The enzyme
nucleoside monophosphate kinase converts UMP and
ATP to
uridine diphosphate (UDP) and
ADP. In the presence of excess ATP, the enzyme
ribonucleotide reductase initiates a chain reaction with UDP, which catalyzes the formation of deoxyuridine diphosphate (dUDP), which is then converted to deoxyuridine triphosphate (dUTP), then deoxyuridine monophosphate (dUMP) via the addition or removal of phosphate groups. == Interactive pathway map ==