MarketAssertio Therapeutics
Company Profile

Assertio Therapeutics

Assertio Therapeutics, Inc. is an American specialty pharmaceutical company. It mainly markets products for treatment in neurology, pain and diseases of the central nervous system. Depomed was founded in 1995 and is headquartered in Newark, California. It is a publicly traded company on NASDAQ, with several products approved by the United States Food and Drug Administration (FDA). On August 15, 2018, the company announced its name change from Depomed, Inc., to Assertio Therapeutics, Inc. As of 2019, Assertio markets three products approved by the FDA: Gralise, Cambia, and Zipsor.

History
1995-2009 Depomed was founded in 1995 2003 saw a net loss of $30 million, compared to $13.5 million in 2002. In 2004, John W. Fara was president, CEO, and chairman. In April 2006, Depomed entered a license agreement with Esprit Pharma over Proquin XR, a "prolonged-release formulation of ciprofloxacin hydrochloride" to treat urinary tract infections. In July 2008, the FDA released a warning about drugs such as Depomed Inc's Proquin XR, an antibiotic, about the risk of tendonitis and ruptured tendons. 2010-2014 By 2010 the company was based in Menlo Park, California, and stated it intended to become profitable in 2011. By 2010, Depomed was supplying its entire logistics system with plastic pallets, after it had to recall a shipment of the diabetes drug Glumetza for potential contamination of wood pallets. As of March 2011, Carl A. Pelzel was CEO and president of Depomed. Depomed had one approved product on the market, Gralise, and had one other approved but not released: Glumetza. That month, Boehringer Ingelheim purchased the rights to use Depomed's Acuform manufacturing technology. On June 21, 2012, Depomed acquired the rights to Zipsor, an NSAID made by Xanodyne Pharmaceuticals. In particular, the Zipsor Liquid Filled Capsules were acquired. Revenue generated by Zipsor was approximately as within the twelve months from June 2011 to May 2012. For $240 million, DL BioPharma purchased the royalty rights to Depomed's Glumetza, a type 2 diabetes drug, in October 2013. The year prior, Depomed had generated $43 million in royalty revenue off the drug. 2015-2017 In January 2015, Assets in 2015 came to $1.3 billion. Equity that year was $315 million, In early April 2016, activist investor Starboard Value accused DepoMed of being "unfriendly to shareholders," noting in part a plan to relocate from California to Delaware. Several weeks later, the Delaware move was dropped. In September 2016, there were reports that Depomed was considering a sale, after Starboard called for the option to be explored in April 2016. In October 2016, Starboard Value struck a deal with Depomed that gave the former three more spots on Depomed's board. In March 2017, more activity by activist investors resulted in CEO Jim Schoeneck being replaced by Arthur Higgins. Nucynta's rights were sold to Collegium Pharmaceutical, for $10 million upfront and royalty payments until December 2022. By March 2019, Assertio's stock had lost half its value since 2016. In September 2019, ''Crain's Chicago Business'' argued that Assertio's diversification campaign was "sputtering", with Assertio stock having dropped 80% in the prior year. Operating income in 2019 was $3.33 million. == Products and manufacturing ==
Products and manufacturing
By 2010 the company was based in Menlo Park, California, and was known for improving "the bio-availability of generic drugs by using polymers usually used in the food and cosmetics industry to reduce side effects and lower the doses necessary for oral medications." The company's products include Gralise, Cambia, Lazanda, Zipsor, and DM-1992, which mainly focus on pain, neuropathic pain, and central nervous system diseases. The drug has also received Orphan Drug designation from the FDA. The company's diabetes treatment, Glumetza (metformin hydrochloride extended release tablet), was approved for the treatment of type II diabetes in adults, and is sold in the US by Valeant. == Former products ==
Former products
Assertio Therapeutics previously owned Nucynta ER and Nucynta IR. On January 15, 2015, Depomed announced the acquisition of the Tapentadol(Nucynta) franchise from Janssen Pharmaceutica for in cash. The transaction closed on April 2, 2015, and the products were relaunched in June 2015 after a major sales force expansion. After Hurricane Maria in 2017 the company faced major shortages of the drug due to the manufacturing plant location in Puerto Rico. In January 2018, after less than 3 years, the manufacturing rights of Nucynta were sold for just $10 million upfront with a $135 million in royalties for the first 4 years. Tapentadol is now produced for the US and Canadian market by Collegium Pharmaceutical. == Lawsuits ==
Lawsuits
The company has been active in patent litigation. In 2002, the company received $18 million from the Bristol-Myers Squibb Company concerning a patent litigation settlement. In August 2018, Purdue Pharma paid Assertio $62 million to settle a patent infringement lawsuit. The suit had been filed in 2013, alleging Purdue infringed on certain patents relating to OxyContin. The company has faced a number of lawsuits related to its marketing of the Nucynta opioid painkiller, with Assertio denying wrongdoing. In March 2019, Assertio won a dismissal of a lawsuit by shareholders that accused the company of hiding how much its growth was dependent on Nucynta marketing for off-label purposes. According to the judge, the plaintiffs failed to provide evidence of a scheme. == See also ==
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