Descent into Limbo or Descent into Hell is an oil-on-panel painting executed c. 1530–1535 by the Italian Renaissance painter Domenico Beccafumi, now in the Sienese Grand Masters room in the Pinacoteca Nazionale in Siena. With the Saint Martin Nativity and Holy Family with the Infant John the Baptist it is one of the last works commissioned from the artist by the Beccafumi Marsili family for their family chapel at the Basilica of San Francesco in Siena. Damaged by a fire in 1655, the painting was seen by Giorgio Vasari, who praised it for the uniqueness of its figures, prefiguring Mannerism.