Early career Scott played for the
Vancouver Whitecaps FC from 2006 to 2012. In 2006, Scott appeared in five matches for the Caps (450 minutes), contributing to the team winning their second W-League title that season.
Notts County Ladies of the English
FA WSL announced that they had signed Scott in January 2014, but she was subsequently included on the list of Canadian players allocated to the NWSL for 2014.
Notts County In February 2014, after more than a month of speculation and legal delays, Scott was officially signed by
Notts County of the
FA WSL. She missed the first half of the
2015 season while preparing for the World Cup with Canada, but returned in time for the
2015 FA Women's Cup Final at
Wembley Stadium, which County lost 1–0 to
Chelsea. She left the club in February 2016 after making 20 league appearances.
Return to FC Kansas City In February 2016, it was announced that Scott would play for
FC Kansas City for the 2016 season of the
National Women's Soccer League via the
NWSL Player Allocation.
Utah Royals FC In February 2018, the
Canadian Soccer Association announced that Scott would play for the
Utah Royals FC during the 2018 season of the
National Women's Soccer League via the
NWSL Player Allocation. She opted out of play during the
2020 NWSL Challenge Cup and the NWSL Fall Series.
Kansas City Current Utah Royals FC folded in December 2020 and her playing rights were transferred to the
Kansas City Current. In October 2024, Scott announced that she would retire from the NWSL at the end of the
2024 season.
Ottawa Rapid FC In January 2025, she signed with
Northern Super League club
Ottawa Rapid FC. Scott scored her first professional goal, in the club's first ever match on April 27, 2025 against
AFC Toronto. On September 22, 2025, Scott announced that she would retire from playing professional soccer following the end of the
2025 season. Speaking about her final season, she said "I only hope that in my time playing for the Ottawa Rapid, I’ve helped inspire those around me through my play and my tenacious yet joyful spirit on the pitch," and that “Closing out the final chapter of my playing career here on Canadian soil, in front of incredible fans in a professional league once dreamed of, has been my honour.” With her team having already clinched a spot in the playoffs, Scott's career was celebrated during the Rapid's final regular season game at home in the
2025 season, at which the Ottawa mayor
Mark Sutcliffe declared October 8 in the city to be "Desiree Scott Day" and fans in the crowd of 2906 donned pink headbands in her honour. ==International career==