Papamichail made her
WTA Tour main-draw debut as a lucky loser at the
2021 Abu Dhabi Open, losing to third seed
Karolína Plíšková in the first round. In June 2021, she won the inaugural $60k
Charleston Pro event by defeating
Gabriela Cé in the final. She was selected to play for Greece at the
2023 United Cup, recording a win over
Isabella Shinikova. Papamichail qualified for the
2023 Pan Pacific Open and defeated lucky loser
Sakura Hosogi, before going out in the second round against sixth seed
Daria Kasatkina. She won her first
WTA125 doubles title at the
2023 Barranquilla Open, partnering with
Valentini Grammatikopoulou to defeat
Yuliana Lizarazo and
María Paulina Pérez García in the final. Partnering
María Lourdes Carlé, she won the doubles title at the
2023 WTA 125 Argentina Open, defeating
María Paulina Pérez García and
Sofia Sewing in the final. She defeated
Maria Mateas to reach the second round at the
2024 Țiriac Foundation Trophy, where she lost to
Kathinka von Deichmann. ==Performance timeline==