Spanoulis started his professional
club career playing with the Greek basketball club
Gymnastikos S. Larissas in the 2001–02 season. He later transferred to several other Greek teams including:
Makedonikos,
Xanthi,
MENT, and
Olympias Patras. Spanoulis reached the
European-wide 2nd-tier level
EuroCup's championship game, with
Makedonikos, during the
2004–05 season. He led the
Greek Second Division in scoring, with
Xanthi, during the 2006–07 season, with a scoring average of 27.4 points per game. As a result, he was voted to the
Eurobasket.com website's Greek 2nd Division All-Domestic Team, All-League First Team, Domestic Player of the Year, Guard of the Year, and Player of the Year. Spanoulis was offered contracts by several
Spanish Second Division teams, prior to the 2007–08 season, but he was unable to accept them, as he could not leave Greece at the time. He signed with
G.S. Larissas 1928 in 2015, after having not played
professional club basketball since 2012. He retired from playing pro club basketball in November 2016, at the age of 37. ==Personal life==