;Lead cast •
Regine Velasquez as Sampaguita "Sam" Fernandez / Melody ;Supporting cast •
Rufa Mae Quinto as Lady Garcia Mendoza •
Mark Anthony Fernandez as Gary / Ate Kuh •
TJ Trinidad as Martin Valencia •
Glaiza de Castro as Tiffany Mendoza •
Mark Herras as Joey Pepe Smith Fernandez •
Jaya as Barang / Barbra •
Randy Santiago as George del Rosario •
Ynna Asistio as Vanessa •
Boboy Garovillo as Elvis Fernandez •
Gloria Diaz as Paula Abdul-Ah Fernandez ;Recurring cast •
Enzo Pineda as Luke •
Gretchen Espina as Debbie Romasanta • Michelle O'Bombshell as Elton •
Chariz Solomon as Did •
Caridad Sanchez as Aretha Abdul-Ah •
Yassi Pressman as Olivia • Nadia Montenegro as Madonna •
Vangie Labalan as Glo • Odette Khan as Eva • Mang Enriquez as Barry Manilow •
Diego Llorico as Cams •
Carmen Soriano as Martin's mom •
Chinggoy Alonzo as Martin's dad • Masculados •
Rochelle Pangilinan as Kelly Salvador / fake Sampaguita "Sam" Fernandez •
Sheena Halili as Lilet • Mitch Valdez as Mother Superior •
Radha as Maria •
Pinky Amador as Leonora •
Eva Castillo as Theresa • Scarlett as Bertha •
Tony Mabesa as a priest •
Elizabeth Ramsey as Turner •
Sef Cadayona as Marlon Legaspi •
Arci Muñoz as Natalie •
Dion Ignacio as Jay Z • Alvin Aragon as Randy • Sweet Ramos as younger Sampaguita • Nikki Bagaporo as teenage Sampaguita and Stevie •
Sandy Talag as Charice • JM Reyes as Mandy •
Renz Valerio as Lee • Jason Abergido as Aaron • Peejay as Andrew •
Vicki Belo as herself •
Bearwin Meily as Rey Toke •
Mike Hanopol •
Victor Wood •
Dexter Doria as Lady and Tiffany's mom • Djanin Cruz as Marie •
German Moreno as Vernes •
Rachelle Ann Go as Demi •
Carlo Aquino as Joe •
Beverly Salviejo as Beth •
Ogie Alcasid as himself •
Dingdong Dantes as himself •
Vaness del Moral as teenage Eva •
Frencheska Farr as a host •
Gian Magdangal as a host •
Raymond Gutierrez as a talk show host ==Production==