Domínguez won the
Carlos Torre Repetto Memorial in
Mérida, Yucatán, Mexico in 2001. He won the
Cuban Chess Championship in 2002, 2003, 2006, 2012 and 2016. Also in 2002, he shared first place with
Lázaro Bruzón in the
North Sea Cup in
Esbjerg, Denmark. During the
FIDE World Chess Championship 2004 he reached the quarterfinals, losing to
Teimour Radjabov in the tie-break. In the same year, Domínguez Pérez won the
Capablanca Memorial for the first time. He won this tournament also in 2008 and 2009. In 2006, Domínguez won the
Magistral Ciutat de Barcelona tournament in
Barcelona scoring 8/9 points, ahead of
Vasyl Ivanchuk, with a
performance rating of 2932. In 2008, he won the "CPA" chess tournament and the 43rd Capablanca Memorial tournament. In the same year, he tied for first with
Evgeny Alekseev at the
Biel Chess Festival, ahead of
Magnus Carlsen. Domínguez Pérez finished second after losing the playoff. On November 8, 2008 Domínguez Pérez won the
World Blitz Championship, held at
Almaty in
Kazakhstan, scoring 11½ points out of 15, ahead of
Vassily Ivanchuk,
Peter Svidler,
Alexander Grischuk and many other top grandmasters. In June 2013 he won the
FIDE Grand Prix event in
Thessaloniki as a clear first in a field of twelve elite players, among them
Fabiano Caruana,
Veselin Topalov and
Alexander Grischuk. In 2016, Domínguez Pérez shared 2nd−4th places at the
Dortmund Sparkassen Chess Meeting with
Vladimir Kramnik and
Fabiano Caruana. Later in the same year, he won the individual silver medal playing board one for the Cuban team in the
42nd Chess Olympiad in
Baku. He was a second for Fabiano Caruana in the
2018 World Chess Championship In December 2018, Domínguez Pérez
transferred federations to represent the United States. Through February and March 2022, Domínguez played in the
FIDE Grand Prix 2022. In the first leg, he won his pool with a 4/6 result by also defeating
Wesley So in rapid tiebreakers. In the third leg, he finished third in Pool B with a result of 3/6, finishing eighth in the standings with nine points. In April 2022 he participated in the
American Cup. He won the 2nd place in the 2019
U.S. Chess Championship and 3rd place in the 2022 U.S. Chess Championship. Domínguez won 2nd place in the 2023
Sinquefield Cup. He served as a replacement for
Ding Liren, who withdrew from the competition in the weeks leading up to the event. ==Notable games==