Although Nelson has created representational images, she has primarily worked in a fluid, abstract vein that writers suggest confront the traditions of
Abstract Expressionism head-on and build on
Joan Miró's anti-paintings, which used nontraditional materials and processes to disrupt painting conventions.
Artforum likened her "exhilarating" willingness to take risks to that of
Sigmar Polke. Critics especially note her "adventurously tough-minded approach to process," which "flirts with painting’s destruction" in favor of dissonant techniques, surfaces, and colors. Noting Nelson's anarchic refusal to adhere to an easily identifiable style, writers have observed that her exhibitions can appear like compendiums of modern and contemporary painting thought. Nelson regards herself as a process artist rather than an
expressionist, emphasizing the primacy of chance, improvisation, and touch in her process. Figurative paintings, such as
Summer Man (1983), presaged future directions with glued, clothing-like pieces of muslin, saturated color, and increasing abstraction. In this period, she regularly incorporated unconventional materials such as cheesecloth, muslin, gels, and modeling paste. She also began employing unorthodox techniques that combined control and accident to "disrupt" her paintings, such as pouring latex enamel paint over gridded fields (the "12 Stations of the Subway" series, 1997–8), making charcoal rubbings of highly textured, existing paintings (her ghostly "Rubbings," 2002), or adhering wadded, paint-soaked muslin to canvasses. Describing this passage in Nelson's work through the painting
Octopus Blue (1990), Klaus Kertess wrote, "We are confronted by an organism wrestling with its self-formation—complex, mysterious, fierce, playful, sensual." In 2016, Nelson returned to the figure in her two-sided, variously constructed "Box" works—free-standing, door-sized painted panels that verge on architecture and continue to employ unconventional materials and processes. as a "loose, kaleidoscopic maze of contrasting viewpoints" and interacting works—a sense furthered by the central, abstracted figures Nelson portrays in them. Critics such as
Dan Cameron noted Nelson's disruption of the frontality of conventional painting, as well as the evolution of the physical presence of her two-sided works into a new, metaphorical level. ==Awards and collections==