Nesti was the first Duquesne president selected by a search committee rather than appointed directly by the
provincial of the Holy Ghost Fathers. At the time of his appointment, he was the director of planning, research, and renewal for the Eastern Province of the Holy Ghost Fathers and the director of the Immaculate Heart of Mary Seminary in
Bethel Park. The announcement of Nesti's selection was made on April 18, 1980, and he assumed office on the following July 1. His formal inauguration was held on October 3, 1980. Nesti's administration at Duquesne met with controversy. He clashed with student groups on campus, including the
Tamburitzans and the staff of the
Duquesne Duke. While the
Duke staff was chastised by the administration because of a "vulgar" and "tasteless"
April Fools' Day edition of the paper, the Tamburitzans were angered at the cancellation of a 1987 world tour and investigation into their institutional practices by Academic Vice President Rolando Bonachea. Nesti also met with objections by the faculty senate on his handling of academic affairs, as well as resistance by students on campus policies. In light of these controversies, a vote of "no confidence" in the administration was issued by the Student Government Association on April 2, 1987. The Nesti administration did, however, see many positive achievements, such as the construction of the
A.J. Palumbo Center, which was begun in 1986 and completed in 1988. The university also made great progress in its academic quality, but persistent divisive issues in the university community forced Nesti's resignation on July 30, 1987. At the time, the
Pittsburgh Post-Gazette opined that "Donald Nesti pursued a commendable goal—a renewed commitment to excellence and accountability—in a clumsy and insensitive manner". The university's Academic Vice President, Dr. Bonachea, served as acting president until the spring of 1988 and the selection of Dr.
John E. Murray, Jr. as Duquesne's eleventh president. Dr. Bonachea had been a supporter of Nesti, and stated that despite the popular reaction against his administration, "Father Nesti was right. In my opinion, he is a man of truth and principle who was determined to protect the welfare of each student." ==Work at St. Thomas University==