Upon her return from France to Egypt in 1940, Shafik hoped to contribute to the education of her country's youth, but the dean of the Faculty of Literature of
Cairo University denied her a teaching position on the pretext that she was "too liberal." The first issue came out in November 1945 and was almost immediately sold out. In 1948 Shafik created the Bint Al Nil Union to help solve women's primary social problems and to ensure their inclusion in their country's policies. The union also worked to eradicate illiteracy by setting up centres for that purpose throughout the country, set up an employment office and a cafeteria for working women. Shafik was deeply inspired by
Huda Sha'arawi, the pioneering Egyptian feminist leader and founder of the Egyptian Feminist Union, and she was even more determined to lead the feminist struggle after Sha'arawi's death in 1947. In the memorial that took place on the 40th day of Sha'arawi's death, she gave a speech galvanizing the attendees to keep fighting for women's rights and stay committed to the demands of equality and justice. In her speech, she said, "This fortieth day after the death of Huda Shaarawi conveys the weight of everything she has done for the Egyptians and for all the people of the Orient. Remember her, because remembrance serves to reinforce faith and because she has struggled to create a proud and cultured society. Remember her until you understand your indebtedness to her. She lived for you, and she has also died for you. And I shall make sure that mourning helps us to continue what she began… You must struggle to reinforce her memory."
Storming Parliament In February 1951, she managed to secretly bring together 1500 women from Egypt's two leading feminist groupings (Bint Al Nil and the
Egyptian Feminist Union). She organized a march of people that interrupted parliament for four hours after they gathered there with a series of demands mainly related to women's socioeconomic rights.
Mufidah Abdul Rahman was chosen to defend Shafik in court in regards to this. However, in spite of receiving promises from the President of the Senate, women's rights experienced no improvements. She ended her strike upon receiving a written statement that President Naguib was committed to a constitution that respected the rights of women.
Trip around the world As a result of the interest sparked by her hunger strike, Doria Shafik was invited to lecture in Asia, Europe and the United States about Egyptian women. She travelled to Italy, England, France, the United States, Japan, India, Ceylon and Pakistan.
Right to vote As a result of Doria Shafik's efforts, women were granted the right to vote under the constitution of 1956, with the proviso, however, that they must be literate, which was not a prerequisite for male voting.
Second hunger strike In 1957 Shafik undertook a second hunger strike in the Indian embassy, in protest over President
Gamal Abdel Nasser's dictatorial regime. As a result, she was put under house arrest by Nasser, her name was banned from the press and her magazines from circulation. several volumes of poetry published by Pierre Fanlac, and her own
memoirs that were translated into many languages. Poetry from her final days was translated by Nadeen Shaker and published in
The Cairo Review: {{Blockquote|text= Daughter of the Nile I have demanded women’s rights My fight was enlarged to human freedom And what was the result? I have no more friends. So what? Until the end of the road I will proceed alone. ==Seclusion and death==