In 1968, five-year old John Dolittle displays an ability to hear what
animals are saying, starting with his own
dog. John asks his dog questions like: "Why do dogs sniff each other's butts?" and the dog's response is that it is their own way of
shaking hands, and John does it when meeting his new
principal Mr. Galvin. His behavior concerns his father Archer, who hires a local
priest to perform an
exorcism on John in order to remove the "devil" from him. During the exorcism, the dog bites and attacks the priest, resulting in Archer sending the dog away. Following this ordeal, John eventually stops talking to animals and soon forgets he can. Thirty years later in 1998, John is a
doctor and a
surgeon living in
San Francisco,
California. He is happily married to his wife Lisa, and has two daughters, typical teenager Charisse, and nerdy Maya, who has a pet
guinea pig named Rodney, and what she believes is a
swan egg, which she hopes will bond with her upon hatching. A large medical company owned by Mr. Calloway seeks to buy John's practice, a deal which one of his colleagues, Dr. Mark Weller, is enthusiastic about, though their other colleague, Dr. Gene Reiss, is skeptical about the deal due to the potential of downsizing patients and staff. John's family goes on vacation, while John goes back to work to see a patient, and then pick up Rodney. On his way home, he accidentally nearly hits a dog with his
SUV, causing the dog to scold him in anger. Afterward, as John is driving to the cabin his family is staying at with Rodney in the car, Rodney starts talking to John, causing him to believe he is having a mental breakdown. John has a
CT scan after animals start asking for favors when he helps a hurt
owl, and he then unwittingly adopts the dog he nearly ran over, eventually naming him Lucky. John later starts secretly helping various animals, including a suicidal circus
tiger named Jake, who suffers from vision problems and crippling headaches. Through all this, John begins learning to re-appreciate his gift, at one point confiding to both Lucky and Mark that he hasn't felt excited about his work in years. However, Lisa and Mark catch him performing
CPR on a
rat, and have him sent to a
mental hospital. Believing his gift is a hindrance, John rejects all abnormality in his life and returns to work, but in doing so, ostracizes Maya as well, who comes to believe he dislikes her. Maya admits to Archer that she liked the idea of her father talking to animals, and John has a change of heart when he eavesdrops on the conversation. He admits to Maya that he does not like, but loves her for who she is, and encourages her to continue being what she wants to be. John then apologizes to Lucky, and together, they sneak Jake out of the circus and take him to the hospital to perform surgery on him, on the same night a party is going on where Calloway will buy the company. Mark and Gene catch John, but Gene tires of Mark's greedy attitude and decides to assist John. Soon, Jake, his symptoms worsening to the point of becoming gravely ill, is exposed in front of everyone at the party, and they all watch as John and Gene operate on Jake in the operating theater. Archer reveals to Lisa that John's gift is real, encouraging her to venture into the theater and keep Jake calm while John and Gene discover Jake is suffering from a
blood clot in his
great cerebral vein and successfully remove it, saving Jake's life. Calloway is impressed with John's efforts and offers to buy the place, though John declines Calloway's offer. John becomes both a doctor and a
veterinarian afterwards, embracing his ability to talk to animals. Maya's egg hatches into a baby
alligator, and the final scene shows John and Lucky walking on the street together with John talking about how he's going to treat animals and people, and Lucky talking about how he wants different treatment from now on, while the owl is shown chasing after the rats. ==Cast==