Dr. John Hugh Gillis Regional High School is a secondary school located in Antigonish, Nova Scotia, Canada. It is attended by approximately 823 students in grades 9 to 12. The school used to fall under the jurisdiction of the Strait Regional School Board, until the school board system was cancelled in the 2018–19 school year. Dr. John Hugh Gillis Regional High School was ranked fourth among Nova Scotian schools in 2009.