De Matteo's role in
The Sopranos helped launch her career. She has appeared in several films, including
Swordfish,
Deuces Wild,
The Perfect You,
Prey for Rock & Roll and the 2005 remake of
John Carpenter's 1976 action film
Assault on Precinct 13. She had the starring role in
Abel Ferrara's
R Xmas, for which she received positive reviews. In 2004, De Matteo won an Emmy for Best Supporting Actress (Drama) for her role as Adriana on
The Sopranos (season 5) and was nominated for a
Golden Globe the same year for the same role. From 2004 to 2006, De Matteo portrayed
Joey Tribbiani's sister Gina on
Joey. De Matteo played the role of
Wendy Case in the series
Sons of Anarchy. The pilot episode aired September 3, 2008, and De Matteo continued making regular appearances into the series' sixth season. She was promoted to a series regular for the seventh and final season. De Matteo played
Angie Bolen, the mother of the Bolen family, on season 6 of the show
Desperate Housewives. She left
Desperate Housewives at the season 6 finale in 2010, for personal reasons. In 2012, she guest-starred in
Californication. De Matteo played the stepmother of Steve Wilde, the main character of the FOX comedy
Running Wilde, appearing in season 1, episode 9. De Matteo co-starred as Krissi Cates in the film adaptation of
Dark Places (2015). In 2015, she was cast as Det. Tess Nazario in the
NBC drama series
Shades of Blue. De Matteo and Chris Kushner began hosting a rewatch podcast of
The Sopranos on March 13, 2020, called
Made Women; in July, the podcast was retooled and renamed
Gangster Goddess Broad-Cast. In September 2022, De Matteo announced she would open an account on
OnlyFans. It went live in August 2023. She claimed her refusal to get the
COVID-19 vaccine put her out of work and led her to join the website. ==Personal life==