MarketDrospirenone/estetrol
Company Profile

Drospirenone/estetrol

Drospirenone/estetrol, sold under the brand name Nextstellis, among others, is a fixed-dose combination medication containing drospirenone, a progestin, and estetrol, an estrogen, which is used as a combined birth control pill for the prevention of pregnancy in women. It is taken by mouth.

Medical uses
Drospirenone/estetrol is used as a combined birth control pill to prevent pregnancy in women. ==Side effects==
Side effects
Estetrol-containing birth control pills, similarly to estradiol-containing birth control pills, may have a lower risk of venous thromboembolism (VTE) than ethinylestradiol-containing birth control pills based on studies of coagulation. However, it is likely that another decade will be required before post-marketing epidemiological studies of VTE incidence with these birth control pills are completed and able to confirm this. ==Pharmacology==
Pharmacology
Pharmacodynamics Drospirenone/estetrol has a much lower impact on liver protein synthesis, including of sex hormone-binding globulin, angiotensinogen, and coagulation factors, than does ethinylestradiol/drospirenone. ==Society and culture==
Society and culture
Legal status Drospirenone/estetrol is approved for the use of hormonal contraception in the European Union, the United States, and Canada. Brand names Drospirenone/estetrol in sold under the brand names Nextstellis, Drovelis, and Lydisilka. ==See also==
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