Dry Branch State Natural Area is a small nature preserve located in Lewis, Hickman, and Perry counties in the U.S. state of Tennessee. The land was first designated as a natural area of interest in 1997 when it was owned by International Paper. The Nature Conservancy purchased the land from International Paper in 2006. It was turned over to the state in 2007 and designated as a State Natural Area. The area is protected due to the presence of rare ecosystems supporting the growth of endangered plants, including Tennessee yellow-eyed grass, which is found only in five other locations in the state.